Therapeutic effect of Bafukang suppository on <i>Candida tropicalis</i> infection

LI Yuan; BAO Siwei; ZHENG Tao; DENG Yifang; LIU Li

doi:10.12299/jsues.23-0232

Volume 39 Issue 1

May 2025

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Article Navigation > Journal of Shanghai University of Engineering Science > 2025 > 39(1): 79-85

LI Yuan, BAO Siwei, ZHENG Tao, DENG Yifang, LIU Li. Therapeutic effect of Bafukang suppository on Candida tropicalis infection[J]. Journal of Shanghai University of Engineering Science, 2025, 39(1): 79-85. doi: 10.12299/jsues.23-0232

Citation:

LI Yuan, BAO Siwei, ZHENG Tao, DENG Yifang, LIU Li. Therapeutic effect of Bafukang suppository on Candida tropicalis infection[J]. Journal of Shanghai University of Engineering Science, 2025, 39(1): 79-85. doi: 10.12299/jsues.23-0232

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Therapeutic effect of Bafukang suppository on Candida tropicalis infection

doi: 10.12299/jsues.23-0232

LI Yuan^{1, 2
,},
BAO Siwei³,
ZHENG Tao²,
DENG Yifang^{1, 2},
LIU Li^{1, 2
,
,}

1.
School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
2.
Center for Pharmacological Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China
3.
Department of Pharmacy, Shanghai East Hospital, Shanghai 200123, China

Received Date: 2023-11-20
Publish Date: 2025-05-19

Abstract

Abstract

To verify the efficacy of Baofukang suppository against Candida tropicalis in vivo and in vitro, a total of 16 clinical strains of Candida tropicalis were collected. The minimum inhibitory concentration (MIC) of Baofukang suppository against Candida tropicalis was determined using microbroth dilution method. The impact on biofilm formation was evaluated by crystal violet staining method, and the alternations in fungus structure was observed using scanning electron microscope (SEM). The vaginal Candida tropicalis infection model in mice was established, changes in vaginal fungus load and vaginal pathology after giving Baofukang suppository were monitored. The results show that Baofukang suppository can inhibit the proliferation and biofilm formation of Candida tropicalis, destroy the cell wall and membrane of Candida tropicalis, effectively relieve vaginal inflammation in mice. Baofukang suppository had obvious inhibitory effect on the growth of Candida tropicalis in vitro and ameliorative effect on vaginitis caused by Candida tropicalis infection in vivo.
- Baofukang suppository,
- Candida tropicalis,
- antifungal effect in vitro,
- pharmacodynamics in vivo

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References(15)

References

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