Mechanism of a drug pair of Astragalus membranaceus and Lycium barbarum<italic/> on ulcerative colitis based on network pharmacology

HAO Fangjia; PENG Yuanyuan; ZHAO Linjing

Volume 35 Issue 4

Feb. 2022

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HAO Fangjia, PENG Yuanyuan, ZHAO Linjing. Mechanism of a drug pair of Astragalus membranaceus and Lycium barbarum on ulcerative colitis based on network pharmacology[J]. Journal of Shanghai University of Engineering Science, 2021, 35(4): 377-382.

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HAO Fangjia, PENG Yuanyuan, ZHAO Linjing. Mechanism of a drug pair of Astragalus membranaceus and Lycium barbarum on ulcerative colitis based on network pharmacology[J]. Journal of Shanghai University of Engineering Science, 2021, 35(4): 377-382.

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Mechanism of a drug pair of Astragalus membranaceus and Lycium barbarum on ulcerative colitis based on network pharmacology

School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China

Received Date: 2021-09-28
Publish Date: 2022-02-23

Abstract

Abstract

The drug pair comprising of Astragalus membranaceus and Lycium barbarum (AL) has the clinical efficacy to prevent ulcerative colitis (UC). However, the mechanism of action is still arcane. The possible mechanism of this drug pair in the treatment of UC was investigated using a network pharmacology platform. The components and putative targets of AL were collected based on integrative pharmacology-based research platform of traditional Chinese medicine, String database, and David database. By analyzing the protein-protein interactive network containing the targets of AL and potential therapeutic targets of UC, GO and KEGG pathway enrichment analyses were performed, and a regulating network of herb-constituent-target-pathway was constructed. The results suggested that AL may play a beneficial role in UC through affecting the expression of targets associated with immune and inflammation such as PTGS2, and regulation of nuclear transcription factor-κВ signaling pathway, TNF signaling pathway, etc. The results of the study provide a reference for the systematic elucidation of the mechanism of AL in the treatment of UC.
- drug pair of Astragalus membranaceus and Lycium barbarum,
- ulcerative colitis (UC),
- network pharmacology,
- mechanism of action

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References(14)

References

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